The Derek Anderson era with the Buffalo Bills (yes [url=http://www.buffalobillsteamonline.com/micah-hyde-jersey]http://www.buffalobillsteamonline.com/micah-hyde-jersey[/url] , you read that sentence correctly) officially begins Sunday when the Bills (2-4) travel to play the Indianapolis Colts (1-5) in a match-up of teams desperate for a win. This Week 7 showdown, Buffalo’s third straight vs. an AFC South foe, doesn’t carry much national appeal. Only fans living in the Buffalo and Indianapolis television markets will get to watch the game as CBS’ featured 1 p.m. Eastern telecast.The Bills opened as a 7.5-point underdog against Andrew Luck and the Colts. Buffalo has not seen an opposing signal-caller throw for 300 or more yards in its last 15 games, the longest current streak in the league. Will Luck snap that streak and pass for 300 yards for the fourth straight game, or will the revamped Bills secondary slow down the aerial attack of Indianapolis? The Colts found a running game in a 42-34 Week 6 loss to the New York Jets, as Marlon Mack rushed for 89 yards on 12 carries, but the Bills will also bring an improving run defense into the game. Since Week 2, the run defense has gone from 22nd to 8th in yards per game (from 113 to 92.5 yards per game).This will be the 70th meeting all-time between these former AFC East rivals. Buffalo leads the all-time series 37-31-1, including prevailing 13-7 in overtime at snowy New Era Field on Dec. 10, 2017, a game the Bills won when LeSean McCoy rambled in from 21 yards out late in the overtime period.The last time the Bills traveled to Indianapolis, the Colts pulled out a 20-13 win on Nov. 25, 2012. Luck tossed an eight-yard TD pass to T.Y. Hilton for a 20-6 lead, his only TD pass of the game, and the Colts prevailed despite C.J. Spiller rushing for 107 yards on 14 carries, Stevie Johnson catching six passes for 106 yards, and Mario Williams posting a three-sack game. Here’s how to watch the game from home:TV ScheduleDate: Sunday, October 21 [url=http://www.buffalobillsteamonline.com/john-miller-jersey]Womens John Miller Jersey[/url] , 2018Time: 1 p.m. EasternChannel: The game will be carried locally on CBS on WIVB 4 in Buffalo, WROC 8 in Rochester, WTVH 5 in Syracuse and Utica, WENY 36-2 in Elmira, and WBNG 12 in Binghamton and Elmira. View the broadcast map.Announcers: Spero Dedes (play-by-play) and Adam Archuleta (analyst). Location: Lucas Oil Stadium | Indianapolis, IndianaRadio: WGR 550AM (Buffalo), WCMF 96.5 FM and WROC 950 AM (Rochester), Fan 590 AM (Toronto), WTKW 99.5 FM and WKTV 105.5 FM (Syracuse), and the rest of the Buffalo Bills Radio Network.Radio Play-by-Play: John Murphy and Mark Kelso in the booth with sideline reporter Sal Capaccio.Online: NFL Game Pass, NFL.com Game CenterFriday Injury Report: Buffalo Bills: Full participant: G Vladimir Ducasse knee, DE Trent Murphy (knee). Did not practice: QB Josh Allen (right elbow), RB Taiwan Jones (neck). Game day status: Ducasse and Murphy are expected to play. Allen and Jones are out. Indianapolis Colts: Full participant: WR T.Y. Hilton (chest/hamstring), OT Margus Hunt (knee), CB Chris Milton (hamstring), OT Al Woods (rest). Limited participant: S Clayton Geathers (concussion/neck), CB Arthur Maulet (hip), TE Erik Swoope (knee). Did not practice: DT/DE Denico Autry (hamstring) [url=http://www.buffalobillsteamonline.com/jordan-poyer-jersey]http://www.buffalobillsteamonline.com/jordan-poyer-jersey[/url] , TE Jack Doyle (hip), WR Ryan Grant (ankle), LB Darius Leonard (ankle), RB Robert Turbin (shoulder), Game day status: Maulet, Milton, and Swoope are questionable, Autry, Doyle, Geathers, Grant, and Turbin are out.Five Buffalo Bills positional battles to watch With only one preseason game remaining, the Buffalo Bills have 87 players on their roster. That means that 34 of the players suiting up on Thursday against the Chicago Bears will not be with the Bills when they open the season against the Baltimore Ravens on September 9. With every preseason, there are positional battles to be waged, won, and lost. Here are five of the battles still brewing that we’ll be watching closely as the Bills play their last exhibition game of the 2018 season.QuarterbackA lot will be known not only by which quarterback starts this game, but also by which quarterback plays little, if at all. Rookie Josh Allen flopped in his starting debut against the Cincinnati Bengals [url=http://www.buffalobillsteamonline.com/ryan-groy-jersey]Womens Ryan Groy Jersey[/url] , and second-year man Nathan Peterman continued his stellar preseason in the very same game. Veteran AJ McCarron should return, and if he starts and plays the majority of the game, it may actually be a tell-tale sign that he has no chance at the starting gig come Week one. Traditionally, the starters play very little, if at all, during a team’s fourth preseason contest. Seeing which quarterback plays the least may actually mean the most in this matchup.Interior Offensive LineThe lack of pass protection on Sunday night played a huge role in Josh Allen’s putrid performance against Cincinnati. While Dion Dawkins and Jordan Mills appear to be the team’s tackles, the interior line has been shuffled about quite a bit. Russell Bodine and Ryan Groy are still battling for the starting center job, with Groy also in the mix for a spot at guard if he should lose the battle of the pivot. John Miller, Vlad Ducasse, and Wyatt Teller are all fighting for one or two starting spots at guard. A lot can happen in the next week, and the last preseason game will be the coaching staff’s final evaluation in a game situation before the real contests begin.Slot Corner/CB2These to are linked because one of the participants is the same in each battle. While rookie Taron Johnson seems to have edged in front of veteran Phillip Gaines for the slot corner job, that doesn’t mean that the latter player will be off the roster. In fact, Gaines supplanted fellow newcomer Vontae Davis at outside corner for a time during the game against the Bengals. The top four corners seem to be set, with Davis, Gaines, Johnson, and Tre’Davious White all near-locks to make the roster. The order in which they will be deployed, however [url=http://www.buffalobillsteamonline.com/vladimir-ducasse-jersey]Womens Vladimir Ducasse Jersey[/url] , still seems very much up for grabs.Backup SafetyHas rookie Siran Neal fallen behind former Carolina Panthers backup Dean Marlowe for a backup safety spot? Neal is more versatile, possessing the ability to play both safety and corner; however, Marlowe is bigger, standing at 6’2” and 205 pounds, perhaps giving head coach Sean McDermott the ability to play a “big nickel” look that he ran during his time in Carolina. With Jordan Poyer and Micah Hyde locked in as the starters, the order in whicht eh backups are deployed on Thursday should give fans some insight into the coaching staff’s thinking.Wide ReceiverI believe that the top five receivers are already set, but the sixth spot is the wild card. Kelvin Benjamin, Zay Jones, Jeremy Kerley, and Corey Coleman should all be on the roster no matter what. Andre Holmes is probably going to remain with the club due mostly to his special teams ability. The team could choose to go with only five receivers, but they could also keep a sixth. Most likely, the decision will come down to veteran Rod Streater, who is once again enjoying a solid camp and preseason, and rookie Ray-Ray McCloud III, who provides youth and explosiveness in the return game. The Bills could keep seven receivers, but I doubt that happens. My gut says that Streater stays and McCloud goes, with general manager Brandon Beane trying to sneak McCloud onto the practice squad.